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Ritonavir or lopinavir/ritonavir tremendously maximize plasma concentrations of oxycodone in healthier human volunteers because of inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin greatly decreases plasma concentrations of oxycodone because of strong induction of CYP3A4.Opioids for example oxycodone hydrochloride might impact the hypothalam